Assistant Professor of Medicine
Department of Medicine, Division of Rheumatology and Department of Immunology
University of California at San Francisco
San Francisco, CA
Mary Beth Humphrey received her MD and her PhD in cell biology from the Baylor College of Medicine in Houston, Texas. Dr Humphrey has lectured at numerous national conventions and has been published in such journals as Proceedings of the National Acadamy of Sciences, Journal of Bone and Mineral Research, and Journal of Immunology.
Project title: DAP12 Associated Receptors in Osteoclast Development
Dr Humphrey is studying the role of a new family of receptors in osteoclasts (large cells that decalcify bone) and how the presence of these receptors regulates the development and function of osteoclasts.
Selected bibliograhy
Humphrey MB, Daws MR, Spusta SC, et al. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res 2006;21:237-45.
Lane NE, Yao W, Nakamura MC, et al. Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. J Bone Miner Res 2005;20:58-66.
Mócsai A*, Humphrey MB*, Van Ziffle JA, et al. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A 2004;101:6158-63.
Humphrey MB, Ogasawara K, Yao W, et al. The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J Bone Miner Res 2004;19:224-34.
Chung D-H*, Humphrey MB*, Nakamura MC, et al. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol 2003;171:6541-8.
