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Ioannis Tassiulas, MD
Assistant Attending Physician
Hospital for Special Surgery
New York, NY
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Ioannis Tassiulas received his MD from the Aristotelian University of Thessaloniki Medical School in Thessaloniki, Greece. He is board certified in internal medicine and rheumatology. Dr Tassiulas has written numerous abstracts and articles, as well as chapters in such textbooks as Primer on the Rheumatic Diseases.
Project title: Dysregulation of IL-10 Signaling in Rheumatic Disease
Dr Tassiulas’ project seeks to clarify how inefficient signaling between various immune system cells may impair the function of interleukin-10 (IL-10). One of these is to suppress tumor necrosis alpha (TNF-α), a factor in abnormal immune response.
Selected publications
Tassiulas I, Kellerman L, Mevorach D, et al. Apoptotic cell phagocytosis inhibits LPS-induced cytokine and chemokine production and IFN-g induced STAT1 activation by macrophages. Human Immunol (submitted).
Tassiulas I, Hu X, Ho H, et al. Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol 2004;5:1181-9.
Sharif NM, Tassiulas I, Hu Y, et al. IFN-α priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J Immunol 2004;172:6476-81.
Ivashkiv LB, Tassiulas I. Can SOCS make arthritis better? J Clin Invest 2003;111:795-97.
Ji JD, Tassiulas I, Park-Min KH, et al. Inhibition of IL-10 signaling after Fc receptor ligation and during rheumatoid arthritis. J Exp Med 2003;197:1573-83.
Tassiulas I, Boumpas DT. Management of lupus nephritis. Part 1: Pathogenesis, clinical, histologic evaluation. J Muscul Med 2003;20:336-40.
Tassiulas I, Boumpas DT. Management of lupus nephritis. Part 2: Contemporary treatment and future directions. J Muscul Med 2003;20:387-90.
Takada K, Danning CL, Kuroiwa T, et al. Lymphocyte depletion with fludarabine in patients with psoriatic arthritis: clinical and immunological effects. Ann Rheum Dis 2003;62:1112-5.
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