Assistant Professor of Pediatrics
Children's Corporate Center
Medical College of Wisconsin
Milwaukee, WI
Dr Verbsky is a clinical fellow in Pediatric Rheumatology/Immunology at Washington University School of Medicine in St Louis.
Project title: Characterization of CD46 Generated T Regulatory Cells
Dr Verbsky is studying T regulatory cells, which help turn off immune responses, in the hope to better characterize them and understand how they regulate immune responses. He and colleagues at Washington University School of Medicine have recently characterized a novel mechanism of immune suppression by CD4+ T regulatory cells which involves granzyme/perforin dependent cytotoxicity. Additionally, he is studying children who develop autoimmune diseases to determine if they have a deficiency or inability to correctly produce these cells.
Selected publications
Kemper C, Verbsky JW, Price JD, et al. T-cell stimulation and regulation: with complements from CD46. Immunol Res 2005;32:31-44
Grossman WJ, Verbsky JW, Tollefsen BL, et al. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 2004;104:2840-8
